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鼠疫耶尔森氏菌pH 6抗原基因的转录分析

Transcriptional analysis of the Yersinia pestis pH 6 antigen gene.

作者信息

Price S B, Freeman M D, Yeh K S

机构信息

Department of Pathobiology, College of Veterinary Medicine, Auburn University, Alabama 36849, USA.

出版信息

J Bacteriol. 1995 Oct;177(20):5997-6000. doi: 10.1128/jb.177.20.5997-6000.1995.

DOI:10.1128/jb.177.20.5997-6000.1995
PMID:7592356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177431/
Abstract

The pH 6 antigen of Yersinia pestis is a virulence protein whose gene, psaA, is positively regulated at the transcriptional level by low pH, mammalian temperature, and an upstream locus, psaE. Low pH appears to be required for initial psaA transcription, although increased temperature is necessary for full expression of the gene. In addition, psaA is monocistronic and its transcript has a relatively long 5' nontranslated region.

摘要

鼠疫耶尔森菌的pH 6抗原是一种毒力蛋白，其基因psaA在转录水平受到低pH、哺乳动物体温及上游基因座psaE的正向调控。虽然该基因的完全表达需要升高温度，但低pH似乎是psaA初始转录所必需的。此外，psaA是单顺反子，其转录本有一个相对较长的5'非翻译区。

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本文引用的文献

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Yersinia pestis pH 6 antigen forms fimbriae and is induced by intracellular association with macrophages.鼠疫耶尔森菌pH 6抗原形成菌毛，并通过与巨噬细胞的细胞内结合而被诱导产生。
Mol Microbiol. 1993 Apr;8(2):311-24. doi: 10.1111/j.1365-2958.1993.tb01575.x.
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Infect Immun. 1990 Aug;58(8):2569-77. doi: 10.1128/iai.58.8.2569-2577.1990.