De Felice M, Damante G, Zannini M, Francis-Lang H, Di Lauro R
Stazione Zoologica Anton Dohrn, Villa Comunale, Napoli, Italy.
J Biol Chem. 1995 Nov 3;270(44):26649-56. doi: 10.1074/jbc.270.44.26649.
The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing protein implicated in the activation of thyroid-specific gene expression. Here we report that TTF-1 is capable of activating transcription from thyroglobulin and, to a lesser extent, thyroperoxidase gene promoters in nonthyroid cells. Full transcriptional activation of the thyroglobulin promoter by TTF-1 requires the presence of at least two TTF-1 binding sites. TTF-1 activates transcription via two functionally redundant transcriptional activation domains that as suggested by competition experiments, could use a common intermediary factor.
甲状腺转录因子1（TTF-1）是一种含同源结构域的蛋白质，与甲状腺特异性基因表达的激活有关。在此我们报告，TTF-1能够在非甲状腺细胞中激活甲状腺球蛋白以及在较小程度上激活甲状腺过氧化物酶基因启动子的转录。TTF-1对甲状腺球蛋白启动子的完全转录激活需要至少两个TTF-1结合位点的存在。TTF-1通过两个功能冗余的转录激活结构域激活转录，竞争实验表明，这两个结构域可能使用一个共同的中间因子。
