1岁及以下婴儿先天性黑素细胞痣的组织学特征。

Histologic features of congenital melanocytic nevi in infants 1 year of age or younger.

作者信息

Barnhill R L, Fleischli M

机构信息

Department of Pathology, Brigham and Women's Hospital, Children's Hospital, Boston, MA 02115, USA.

出版信息

J Am Acad Dermatol. 1995 Nov;33(5 Pt 1):780-5. doi: 10.1016/0190-9622(95)91816-7.

DOI:10.1016/0190-9622(95)91816-7

PMID:7593778

Abstract

BACKGROUND

Congenital melanocytic nevi (CMN) occur in approximately 1% of the white population. These lesions are often surgically excised prophylactically because of increased melanoma risk.

OBJECTIVE

In this study 87 CMN of all sizes from infants 12 months of age or younger (mean age, 6.6 months) were examined histologically.

METHODS

Each lesion was evaluated for depth of nevus cell involvement, overall epidermal and dermal pattern, and cytologic atypia.

RESULTS

Most CMN involved the lower half of the reticular dermis (89%), and 51% infiltrated the subcutaneous tissue. Depth of nevus cell infiltration was positively correlated with size of the lesion. The predominant dermal pattern was diffuse interstitial infiltration (63%). Patchy nevus cell patterns were observed in 37% of the CMN and were associated with smaller lesions (p < 0.001). Most of the CMN displayed no cytologic atypia (70%), and we found no cases of melanoma. Atypia was not significantly associated with either size or location of the nevus.

CONCLUSION

These results indicate that depth and pattern of nevus cells are directly related to size of CMN in infants.

摘要

背景

先天性黑素细胞痣（CMN）在约1%的白种人群中出现。由于黑素瘤风险增加，这些病变常被预防性手术切除。

目的

本研究对12个月及以下婴儿（平均年龄6.6个月）的87个各种大小的CMN进行了组织学检查。

方法

对每个病变评估痣细胞累及深度、整体表皮和真皮模式以及细胞异型性。

结果

大多数CMN累及网状真皮下半部（89%），51%浸润皮下组织。痣细胞浸润深度与病变大小呈正相关。主要的真皮模式为弥漫性间质浸润（63%）。37%的CMN观察到斑片状痣细胞模式，且与较小病变相关（p<0.001）。大多数CMN无细胞异型性（70%），且未发现黑素瘤病例。异型性与痣的大小或位置均无显著相关性。