Shirai T, Takagi A, Kurumada T, Ohta U, Kobayashi H, Harasawa S, Miwa T
Department of Internal Medicine VI, Tokai University School of Medicine, Isehara, Japan.
J Clin Gastroenterol. 1995;20 Suppl 2:S128-31. doi: 10.1097/00004836-199506002-00035.
Helicobacter pylori eradication therapy combining amoxicillin (AMPC), plaunotol (PL), and a proton pump inhibitor (PPI) was examined as an alternative to triple therapy, which has a high rate of side effects and low patient compliance. Thirty-two H. pylori-positive patients (24 men, 8 women) with duodenal ulcers were examined. The diagnosis of H. pylori infection was made by the urease test on specimens biopsied from two sites in the stomach. Simultaneously, the IgG antibody against H. pylori was measured by the EIA method. The therapeutic regimen was lansoprazole (LPZ) 30 mg q.d. (6 weeks) and AMPC 1,500 mg t.i.d. (2 weeks) plus PL320 mg b.i.d. (6 weeks). The rate of ulcer healing was judged endoscopically after 6 weeks. Cases that become urease-negative after the cessation of the therapy were defined as having achieved clearance, and those negative after 1 month as eradication. Within 6 weeks, 31 of 32 patients had healed ulcers. All patients were H. pylori antibody-positive before therapy. The clearance rate was 71.9% (23/32) and the eradication rate was 45.8% (11/24). Adverse effects were observed only in one case. We conclude that combination therapy with LPZ, AMPC, and PL has a high therapeutic effect on ulcer healing and moderate effectiveness for eradication of H. pylori.
将阿莫西林（AMPC）、普拉诺醇（PL）和质子泵抑制剂（PPI）联合使用的幽门螺杆菌根除疗法作为三联疗法的替代方案进行了研究，三联疗法副作用发生率高且患者依从性低。对32例十二指肠溃疡的幽门螺杆菌阳性患者（24例男性，8例女性）进行了检查。通过对取自胃内两个部位的活检标本进行尿素酶试验来诊断幽门螺杆菌感染。同时，采用酶免疫测定法检测抗幽门螺杆菌的IgG抗体。治疗方案为兰索拉唑（LPZ）30毫克，每日一次（6周），AMPC 1500毫克，每日三次（2周）加PL 320毫克，每日两次（6周）。6周后通过内镜检查判断溃疡愈合率。治疗停止后尿素酶试验呈阴性的病例定义为已清除幽门螺杆菌，1个月后呈阴性的病例定义为已根除。6周内，32例患者中有31例溃疡愈合。所有患者治疗前幽门螺杆菌抗体均为阳性。清除率为71.9%（23/32），根除率为45.8%（11/24）。仅1例观察到不良反应。我们得出结论，LPZ、AMPC和PL联合治疗对溃疡愈合具有较高的治疗效果，对根除幽门螺杆菌具有中等疗效。
