Mine T, Yasuda H, Akimoto K, Katoaka A, Mashima H, Tajima A, Fukujin H, Tsuchida T, Takano T, Nagasawa J
Department of Gastroenterology, University of Tokyo, Japan.
J Clin Gastroenterol. 1995;20 Suppl 2:S75-8. doi: 10.1097/00004836-199506002-00020.
In the present study, the effects of short-term treatment with lansoprazole on healing and recurrence of peptic ulcer were investigated. Complete healing (change to the S2 stage) after 3 or 4 weeks of treatment with lansoprazole was observed in 9.9% of gastric ulcers and 38.3% of duodenal ulcers. Complete healing was observed after 3 or 4 weeks of treatment with lansoprazole in gastric ulcers and was significantly related to the serum titer of IgG anti-Helicobacter pylori antibodies. This was not the case in duodenal ulcers. Complete healing after 6 or 8 weeks of treatment with lansoprazole was not dependent on serum levels of IgG anti-H. pylori antibodies. Short-term treatment by lansoprazole did not affect serum levels of IgG anti-H. pylori antibodies immediately after the end of lansoprazole treatment, but significantly reduced serum levels of IgG anti-H. pylori antibodies were found 9 months after treatment.
在本研究中，调查了兰索拉唑短期治疗对消化性溃疡愈合和复发的影响。在接受兰索拉唑治疗3或4周后，9.9%的胃溃疡和38.3%的十二指肠溃疡实现了完全愈合（转变为S2期）。胃溃疡患者在接受兰索拉唑治疗3或4周后实现了完全愈合，且这与抗幽门螺杆菌IgG抗体的血清滴度显著相关。十二指肠溃疡的情况并非如此。接受兰索拉唑治疗6或8周后的完全愈合并不依赖于抗幽门螺杆菌IgG抗体的血清水平。兰索拉唑短期治疗在治疗结束后即刻并未影响抗幽门螺杆菌IgG抗体的血清水平，但在治疗9个月后发现抗幽门螺杆菌IgG抗体的血清水平显著降低。
