Käyhty H, Ahman H, Rönnberg P R, Tillikainen R, Eskola J
KTL, National Public Health Institute, Helsinki, Finland.
J Infect Dis. 1995 Nov;172(5):1273-8. doi: 10.1093/infdis/172.5.1273.
Sixty-two infants and 31 toddlers were vaccinated with the tetravalent pneumococcal conjugate vaccine PncOMPC consisting of the capsular polysaccharide of pneumococcal types 6B, 14, 19F, and 23F conjugated to the outer membrane protein complex of Neisseria meningitidis. Infants were vaccinated at 2, 4, and 6 months (group A) or at 4, 6, and 14 months (group B); toddlers were vaccinated at 24 or at 24 and 26 months of age. The IgG responses to the four pneumococcal polysaccharide types were measured by EIA. In infants, types 14 and 19F induced a significant response after the first dose and types 6B and 23F after the second dose. A clearcut booster response was seen to the booster dose given at 14 months, indicating immunologic priming by the primary series at 2-6 months of age. The responses of the toddlers to one or two doses of the vaccine were very similar to the responses in infants.
62名婴儿和31名幼儿接种了四价肺炎球菌结合疫苗PncOMPC，该疫苗由肺炎球菌6B、14、19F和23F型的荚膜多糖与脑膜炎奈瑟菌外膜蛋白复合物结合而成。婴儿在2、4和6个月龄时接种（A组）或在4、6和14个月龄时接种（B组）；幼儿在24个月龄时接种或在24和26个月龄时接种。通过酶免疫测定法测量对四种肺炎球菌多糖类型的IgG反应。在婴儿中，14型和19F型在首剂后诱导出显著反应，6B型和23F型在第二剂后诱导出显著反应。在14个月龄时给予的加强剂量后出现了明显的加强反应，表明在2至6个月龄时的初次免疫系列引发了免疫致敏。幼儿对一剂或两剂疫苗的反应与婴儿的反应非常相似。
