O'Broin E S, Earley M J, Smyth H, Hooper A C
J Hand Surg Br. 1995 Aug;20(4):505-8. doi: 10.1016/s0266-7681(05)80164-0.
The risks of foreign implantation may be avoided in tendon repair by the use of absorbable sutures, for example polydioxanone. In this study, the in vivo tensile strength half-life of 4/0 polydioxanone was found to be approximately 4 weeks. Using a rabbit model, we compared polydioxanone tendon repairs with polypropylene tendon repairs. Unilateral flexor digitorum longus repairs were performed on 46 rabbits using either polydioxanone or polypropylene. Tendons were harvested at 3 days, 2 weeks and 4 weeks and the tensile breaking strengths were obtained. 30 intact rabbit flexor digitorum longus tendons and 20 freshly repaired tendons were also tested. By 4 weeks, the repair strength had increased eight-fold from approximately 20 N to 166 N. The sutures made little contribution to the overall strength of a 4-week-old repair. There was no significant difference between polydioxanone and polypropylene repairs at any stage. These results show that polydioxanone repairs were as strong as polypropylene during the first critical weeks of tendon healing.
在肌腱修复中，使用可吸收缝线（如聚二氧六环酮）可避免异体植入的风险。在本研究中，发现4/0聚二氧六环酮的体内抗张强度半衰期约为4周。我们使用兔模型，比较了聚二氧六环酮肌腱修复与聚丙烯肌腱修复。对46只兔子的单侧趾长屈肌腱进行修复，使用聚二氧六环酮或聚丙烯。在术后3天、2周和4周采集肌腱并测定抗张断裂强度。还测试了30条完整的兔趾长屈肌腱和20条新鲜修复的肌腱。到4周时，修复强度从约20 N增加了八倍，达到166 N。缝线对4周龄修复的整体强度贡献不大。在任何阶段，聚二氧六环酮和聚丙烯修复之间均无显著差异。这些结果表明，在肌腱愈合的最初关键几周内，聚二氧六环酮修复的强度与聚丙烯相同。
