Ikeno E, Kubota I, Kondo T, Shibata T, Yamaki M, Tomoike H
First Department of Internal Medicine, Yamagata University School of Medicine, Japan.
J Electrocardiol. 1995 Jul;28(3):237-43. doi: 10.1016/s0022-0736(05)80262-6.
The proximal left circumflex coronary artery (LCx) was cannulated and perfused with blood from the carotid artery in nine open-chest dogs. Perfused blood temperature was modulated by immersing a bypass tube in a temperature-controlled water tank. Two epicardial electrodes were placed, one at the LCx area and one at the left anterior descending coronary artery (LAD) area. The temperature of the autoperfused blood was set at 23 degrees C and was gradually elevated to 42 degrees C during 30 minutes. The QRS, ST-T, and QRST areas, and the activation-recovery interval of the electrode at the LCx area, changed unidirectionally in relation to elevation of the blood temperature. Although the QRS, ST-T, and QRST areas of the electrode at the LAD area changed in proportion to changes in the electrode at the LCx area, the activation-recovery interval of the electrode at the LAD area remained constant in all dogs. During 2-minute occlusion of the proximal LCx (n = 7), the activation-recovery interval of the electrode at the LAD area also remained constant despite the presence of reciprocal electrocardiographic changes. The activation-recovery interval is a useful index for defining whether a change in ST-T in a unipolar electrogram is due to a local electrophysiologic effect or a reciprocal effect.
在9只开胸犬中，将左回旋支冠状动脉近端（LCx）插管，并灌注来自颈动脉的血液。通过将旁路管浸入温度可控的水箱中来调节灌注血液的温度。放置两个心外膜电极，一个位于LCx区域，一个位于左冠状动脉前降支（LAD）区域。自体灌注血液的温度设定为23℃，并在30分钟内逐渐升高至42℃。LCx区域电极的QRS、ST-T和QRST面积以及激活-恢复间期随血液温度升高呈单向变化。尽管LAD区域电极的QRS、ST-T和QRST面积随LCx区域电极的变化而相应改变，但所有犬LAD区域电极的激活-恢复间期均保持恒定。在近端LCx闭塞2分钟期间（n = 7），尽管存在心电图的对应改变，但LAD区域电极的激活-恢复间期仍保持恒定。激活-恢复间期是用于确定单极心电图中ST-T改变是由于局部电生理效应还是对应效应的有用指标。
