Imai S
Department of Pharmacology, Niigata University School of Medicine, Japan.
Jpn Heart J. 1995 Mar;36(2):127-77. doi: 10.1536/ihj.36.127.
To delineate the importance of cyclic GMP (cGMP) as a second messenger for signal transduction within the cell, catalytic and regulatory features of the proteins involved in the synthesis and degradation of cGMP, i.e., guanylate cyclases and phosphodiesterases, are described. Characteristic features of cGMP-dependent protein kinases as intracellular receptors for cGMP and the contribution of this enzyme to the physiological functions of cGMP in the cardiovascular system are discussed.
为了阐明环磷酸鸟苷（cGMP）作为细胞内信号转导第二信使的重要性，本文描述了参与cGMP合成和降解的蛋白质（即鸟苷酸环化酶和磷酸二酯酶）的催化和调节特性。讨论了cGMP依赖性蛋白激酶作为cGMP细胞内受体的特征，以及该酶对cGMP在心血管系统生理功能中的作用。
