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一种用于分析生存动态的老年学距离度量。

A gerontological distance metric for analysis of survival dynamics.

作者信息

Eakin T, Witten M

机构信息

University of Texas System, Department of Applications Research and Development, Austin 78758-4497, USA.

出版信息

Mech Ageing Dev. 1995 Mar 1;78(2):85-101. doi: 10.1016/0047-6374(94)01508-j.

Abstract

A metric for quantifying a gerontological mapping 'distance' or displacement consistent with the historical concept of velocity of aging and with the more recent concept of acceleration of aging, is introduced using the paradigm of a simple linear dynamics system of elementary physics. This analysis is extended to recent analytical methods utilizing intrinsic or internal time scaling so that biological or gerontological similarity can be distinguished from chronological age similarity, not only among various intraspecies populations but also among interspecies populations which may not even have the same underlying mechanisms of senescence or survival distributions. Illustrative examples are provided and discussed. Also, applications involving the comparison of an individual from one population to an individual from another population, when both can be assessed with respect to their respective group properties, are considered.

摘要

利用基础物理学简单线性动力学系统的范式,引入了一种度量标准,用于量化与衰老速度的历史概念以及与最近的衰老加速度概念相一致的老年学映射“距离”或位移。该分析扩展到利用内在或内部时间尺度的最新分析方法,以便不仅在各种物种内种群之间,而且在甚至可能没有相同衰老或生存分布潜在机制的物种间种群之间,能够将生物学或老年学相似性与实足年龄相似性区分开来。提供并讨论了示例。此外,还考虑了涉及将一个种群中的个体与另一个种群中的个体进行比较的应用,前提是两者都可以根据其各自的群体特性进行评估。

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