Liu D, Liu F, Song Y K
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pennsylvania 15261, USA.
Pharm Res. 1995 Apr;12(4):508-12. doi: 10.1023/a:1016289526578.
Inclusion of monosialoganglioside GM1 into liposomes significantly enhances the circulation time of liposomes in mice. Conversely, intravenously injected GM1-containing liposomes were rapidly removed from the blood circulation and accumulated in the liver and spleen in rats. In rats, increasing the GM1 content in liposomes resulted in more rapid clearance from the blood. Increasing the membrane rigidity of liposomes further increased the liver uptake of GM1-containing liposomes. The activity of GM1 in enhancing the liposome uptake by rat liver appears to be mediated by complement components.
将单唾液酸神经节苷脂GM1包封到脂质体中可显著延长脂质体在小鼠体内的循环时间。相反，静脉注射含GM1的脂质体在大鼠体内会迅速从血液循环中清除，并在肝脏和脾脏中蓄积。在大鼠中，增加脂质体中GM1的含量会导致其从血液中清除得更快。增加脂质体的膜刚性会进一步提高含GM1脂质体在肝脏中的摄取量。GM1增强大鼠肝脏摄取脂质体的活性似乎是由补体成分介导的。
