Matsuda K, Kawahara R, Yoshioka S, Katayama S, Sumami M
Department of Neuro-Psychiatry, Faculty of Medicine, Tottori University.
Seishin Shinkeigaku Zasshi. 1995;97(4):199-216.
To study amygdaloid kindling in variously aged infant rats and rekindling development after their maturation, 34 male Wistar rats were subjected to initial kindling 13 days after birth (13-day-old group, 9 rats), 16 days after birth (16-day-old group, 9 rats), 18 days after birth (18-day-old group, 7 rats), or 26 days after birth (26-day-old group, 9 rats). Each group received reoperation on the 70th day, and was subjected to rekindling 5 days after operation. Also, a control group of mature rats was initially kindled at the age of 75 days and rekindled after 2 months (75-day-old group, 11 rats). The obtained results are summarized as follows. I. Results of initial kindling: (1) a significant positive correlation was found between the age of the 4 groups of rats and the after-discharge threshold of infant rats (p < 0.05), (2) significant correlations were not found between the age of the 4 groups of infant rats and the stimulation numbers inducing C0-2 and C0-4 stage symptoms, (3) a significant positive correlation was found between the age of the 4 groups of infant rats and the stimulation number inducing C3-4 symptoms (p < 0.05). II. Results of rekindling: (1) significant negative correlations were found between the age of the 4 groups at initial kindling and the stimulation numbers inducing C0-2, C3-4 and C0-4 symptoms (p < 0.05-0.0001). III. Ratio of initial kindling and rekindling: (1) significant negative correlations were found between the age at initial kindling and the C0-2 and C0-4 stimulation number ratios (p < 0.00001), (2) a negative but not significant correlation was found between the C3-4 stimulation number ratio and age at initial kindling. These results suggest that in infant rats amygdaloid excitability is stronger, when the younger the rat, and that the later in the infant period the epileptogenesis is acquired, the stronger is it preserved even after maturation as high amygdaloid excitability.
为研究不同年龄幼鼠的杏仁核点燃及成熟后再点燃的发展情况，将34只雄性Wistar大鼠在出生后13天（13日龄组，9只大鼠）、16天（16日龄组，9只大鼠）、18天（18日龄组，7只大鼠）或26天（26日龄组，9只大鼠）进行初次点燃。每组在第70天接受再次手术，并在术后5天进行再点燃。此外，成熟大鼠对照组在75日龄时初次点燃，2个月后进行再点燃（75日龄组，11只大鼠）。所得结果总结如下。一、初次点燃结果：（1）4组大鼠的年龄与幼鼠的后放电阈值之间存在显著正相关（p < 0.05），（2）4组幼鼠的年龄与诱发C0 - 2和C0 - 4期症状的刺激次数之间未发现显著相关性，（3）4组幼鼠的年龄与诱发C3 - 4症状的刺激次数之间存在显著正相关（p < 0.05）。二、再点燃结果：（1）4组初次点燃时的年龄与诱发C0 - 2、C3 - 4和C0 - 4症状的刺激次数之间存在显著负相关（p < 0.05 - 0.0001）。三、初次点燃与再点燃的比例：（1）初次点燃时的年龄与C0 - 2和C0 - 4刺激次数比例之间存在显著负相关（p < 0.00001），（2）C3 - 4刺激次数比例与初次点燃时的年龄之间存在负相关但不显著。这些结果表明，幼鼠中，大鼠年龄越小，杏仁核兴奋性越强，且在幼年期获得癫痫发生越晚，即使成熟后作为高杏仁核兴奋性也保留得越强。
