Kamata S
Department of Psychiatry and Neurology, Asahikawa Medical College, Japan.
Hokkaido Igaku Zasshi. 1996 Jan;71(1):95-104.
To investigate the seizure susceptibility in the rat after the mature period, the unilateral (primary site, left) and the subsequent contralateral (secondary site, right) amygdaloid kindling were examined in 2-3-month-old (n = 12, group A), 12-month-old (n = 11, group B), and 18-month-old (n = 7, group C) male Sprague-Dawley rats. At both of the primary and the secondary sites, the number of stimulations required to produce a generalized convulsion with falling (stage 5) increased as the age progressed, and there was a significant difference in the number of stimulations to reach stage 5 between groups A and B, and between groups A and C. These findings suggest that the age-related retardation of the development of amygdaloid kindling reflects aging changes of synaptic transmission. On the other hand, positive transfer effect (a facilitory effect of the primary site amygdaloid kindling on the development of the secondary site amygdaloid kindling) was observed in all of the three groups. This results suggests that both in and after the mature period, the secondary site amygdaloid kindling in the rats utilizes proconvulsant neuroplastic changes in the brainstem that has been already established by the primary site amygdaloid kindling.
为研究成年期后大鼠的癫痫易感性，对2 - 3月龄（n = 12，A组）、12月龄（n = 11，B组）和18月龄（n = 7，C组）的雄性Sprague-Dawley大鼠进行单侧（原发部位，左侧）及随后的对侧（继发部位，右侧）杏仁核点燃实验。在原发部位和继发部位，随着年龄增长，引发跌倒性全身惊厥（5期）所需的刺激次数均增加，且A组与B组之间、A组与C组之间在达到5期的刺激次数上存在显著差异。这些发现表明，与年龄相关的杏仁核点燃发育迟缓反映了突触传递的衰老变化。另一方面，在所有三组中均观察到了阳性转移效应（原发部位杏仁核点燃对继发部位杏仁核点燃发育的促进作用）。这一结果表明，在成年期内及成年期后，大鼠继发部位的杏仁核点燃利用了已由原发部位杏仁核点燃建立的脑干中促惊厥性神经可塑性变化。
