Hachulla E, Janin A
Service de médicine interne, hôpital Claude-Huriez, Lille, France.
Rev Med Interne. 1995;16(5):325-35. doi: 10.1016/0248-8663(96)80718-1.
Inflammatory fasciitis without infection include different entity like eosinophilic fasciitis, the syndrome of eosinophilia-myalgia after tryptophan ingestion, toxic oil syndrome, exposure to trichlorethylene, phenylketonuria skin changes, the syndrome of palmar fasciitis, fasciitis in chronic graft-versus-host disease and fasciitis secondary to an adjacence process. The diagnosis of all these scleroderma-like skin changes is sometimes not easy because the clinical and sometimes the histopathological changes are bordeline manifestations with scleroderma. The most characteristic markers for non infectious fasciitis is eosinophilia and the infiltration of the fascia with eosinophilis, but it may be unremarkable or absent, only frequently present at the onset of the disease. Anamnesis is most important to guide the diagnosis. The eosinophils, but not only, may play a major role in the pathogenesis of this entity.
非感染性炎性筋膜炎包括不同类型，如嗜酸性筋膜炎、色氨酸摄入后嗜酸性粒细胞增多-肌痛综合征、中毒性油综合征、接触三氯乙烯、苯丙酮尿症皮肤改变、掌腱膜筋膜炎综合征、慢性移植物抗宿主病中的筋膜炎以及继发于邻近病变的筋膜炎。所有这些硬皮病样皮肤改变的诊断有时并不容易，因为临床和有时组织病理学改变是与硬皮病的交界性表现。非感染性筋膜炎最具特征性的标志物是嗜酸性粒细胞增多以及嗜酸性粒细胞浸润筋膜，但这可能不明显或不存在，仅在疾病发作时频繁出现。病史对于指导诊断最为重要。嗜酸性粒细胞（但不仅是嗜酸性粒细胞）可能在该疾病的发病机制中起主要作用。
