Olenius M, Johansson O
Department of Plastic and Reconstructive Surgery, Karolinska Hospital, Stockholm, Sweden.
Scand J Plast Reconstr Surg Hand Surg. 1995 Mar;29(1):15-20. doi: 10.3109/02844319509048418.
Tissue expansion generates metabolic and morphological changes in the expanded tissues. The alteration of epidermal and dermal thickness has been investigated in many animal studies, but few human studies have been published. We have studied 11 women whose breasts were reconstructed with tissue expansion after mastectomy. The expanded breast skin was biopsied on three occasions: before expansion, at the time of maximal expansion, and six months after the completed reconstruction. Specimens were prepared for light microscopy and epidermal thickness was assessed. There was a significant increase in epidermal thickness (p < 0.05) at the time of maximal expansion. The values before and at six months after reconstruction were not significantly different from each other. We conclude that the epidermis increases in thickness as a result of expansion and returns to normal thickness six months after cessation of expansion.
组织扩张会在扩张的组织中引发代谢和形态学变化。许多动物研究已对表皮和真皮厚度的改变进行了调查，但发表的人体研究较少。我们对11名在乳房切除术后采用组织扩张进行乳房重建的女性进行了研究。对扩张的乳房皮肤在三个时间点进行活检：扩张前、最大扩张时以及重建完成后六个月。制备标本用于光学显微镜检查并评估表皮厚度。在最大扩张时，表皮厚度显著增加（p < 0.05）。重建前和重建后六个月时的值彼此无显著差异。我们得出结论，表皮因扩张而增厚，并在扩张停止六个月后恢复到正常厚度。
