Winters Z, Mohube P, Gray C, Wright C, Teare J, Lange M, Mannell A, Myburgh J A
Department of Surgery, University of the Witwatersrand, Johannesburg.
S Afr J Surg. 1994 Dec;32(4):135-40.
In vivo bromodeoxyuridine was used to measure the 'bromo' labelling index (LI,%), the duration of the S-phase (Ts, hours) and the potential tumour doubling time (Tpot, days) in women with stages I-IV breast cancer. These were studied in relation to lymph node status, tumour size, histological grade, oestrogen receptor status (ER), ploidy and S-phase fraction (SPF). In our patients, a LI of 10%, a Tpot of 2 days or an SPF of 9-10.5% predicted aggressive breast cancer. The LI was significantly higher (5%) in ER-negative than in ER-positive (2%) tumours (P = 0.03). There was a trend towards increased DNA synthesis in cancers with an SPF over 10% (P = 0.08). ER-negative breast cancers over 2 cm in diameter had shorter median Tpots of 5.3 days (P = 0.02) and 8 days (P = 0.05) compared with smaller, ER-positive tumours. A trend towards faster growth rates was seen in lymph node-positive, high-SPF (> 10%) breast cancers. Tumour kinetics may have additional prognostic value in the selection of node-negative patients for adjuvant therapy.
使用体内溴脱氧尿苷来测量I-IV期乳腺癌女性的“溴”标记指数（LI，%）、S期持续时间（Ts，小时）和潜在肿瘤倍增时间（Tpot，天）。研究了这些指标与淋巴结状态、肿瘤大小、组织学分级、雌激素受体状态（ER）、倍体和S期分数（SPF）的关系。在我们的患者中，LI为10%、Tpot为2天或SPF为9-10.5%预示着侵袭性乳腺癌。ER阴性肿瘤的LI显著高于ER阳性肿瘤（5%对2%）（P = 0.03）。SPF超过10%的癌症中DNA合成有增加的趋势（P = 0.08）。与较小的ER阳性肿瘤相比，直径超过2 cm的ER阴性乳腺癌的中位Tpot较短，分别为5.3天（P = 0.02）和8天（P = 0.05）。在淋巴结阳性、高SPF（> 10%）的乳腺癌中观察到生长速度加快的趋势。肿瘤动力学在选择辅助治疗的淋巴结阴性患者中可能具有额外的预后价值。
