Bass D H, Adams L P, Tregidga A
Department of Paediatric Surgery, University of Cape Town.
S Afr J Surg. 1994 Dec;32(4):149-52.
A controlled study was undertaken to examine the effects of temporary arterial interruption on bone growth in a laboratory rat model. Under general anaesthesia, the right external iliac artery (EIA) was exposed in each of 80 male rats weighing 110-120 g. Twenty of the rats served as sham controls while three groups of 20 rats each underwent ligation of the artery for 6, 24 and 48 hours respectively. All rats underwent measurement of right and left femoral and tibial length 12 weeks after artery ligation. Measurements were performed in vivo using three-dimensional stereoscopic analysis, the method of which is described. Results revealed that EIA ligation for 6 hours had no effect on bone growth but that ischaemia for 24 hours and 48 hours produced leg length discrepancies equalling 3.1% and 3.6% respectively. We conclude that a time-dependent relationship may exist between ischaemia and compromised bone growth in a developing animal.
进行了一项对照研究，以检验在实验室大鼠模型中临时动脉阻断对骨骼生长的影响。在全身麻醉下，对80只体重为110 - 120克的雄性大鼠分别暴露其右髂外动脉（EIA）。其中20只大鼠作为假手术对照，另外三组每组20只大鼠分别接受动脉结扎6小时、24小时和48小时。所有大鼠在动脉结扎12周后测量左右股骨和胫骨长度。使用三维立体分析在体内进行测量，其方法已作描述。结果显示，EIA结扎6小时对骨骼生长无影响，但缺血24小时和48小时分别导致腿长差异达3.1%和3.6%。我们得出结论，在发育中的动物中，缺血与骨骼生长受损之间可能存在时间依赖性关系。
