Louryan S, Heymans O, Goffard J C
Laboratoire d'Anatomie et Embryologie Humaines, Faculté de Médecine (C.P. 619), Université Libre de Bruxelles, Belgium.
Surg Radiol Anat. 1995;17(1):59-63. doi: 10.1007/BF01629502.
Triazene administration to 10-day pregnant mice gave rise to severe ear abnormalities, including middle ear ossicle malformations. The head of the malleus and the body of the incus were sometimes absent. In some instances, the stapes appeared dysplastic. The stapedial artery was often quite dilated, as well as other cephalic vessels, but qualitatively normal. Severe inner ear abnormalities were observed, as well as auditory nerve disruption, which was associated with central nervous system lesions. Multiple haematomas were present in the embryonic face, but ear abnormalities occurred even in the absence of local hemorrhages. We postulate a direct effect of the teratogen on the branchial mesenchyme. This model seems to be useful for the comprehension of human middle ear abnormalities, but does not constitute a phenocopy of hemicranial microscomia.
给怀孕10天的小鼠施用三氮烯会导致严重的耳部异常，包括中耳听小骨畸形。锤骨头部和砧骨体有时缺失。在某些情况下，镫骨发育异常。镫骨动脉以及其他头部血管常常明显扩张，但性质正常。观察到严重的内耳异常以及听神经中断，这与中枢神经系统损伤有关。胚胎面部出现多处血肿，但即使没有局部出血也会发生耳部异常。我们推测致畸剂对鳃间充质有直接作用。该模型似乎有助于理解人类中耳异常，但并不构成半侧颅面微小畸形的拟表型。
