Trott K R, Tamou S, Sassy T, Kiszel Z
Department of Radiation Biology, Medical College of St. Bartholomew's Hospital, London.
Strahlenther Onkol. 1995 Jun;171(6):326-31.
The dependence of the structural and the functional chronic radiation damage in the large bowel of rats was investigated in order to develop criteria for optimising treatment plans.
Rats were locally irradiated to different volumes of their rectum. The resulting chronic damage was determined by clinical observation, by rectoscopy and by histopathology.
The structural damage as well as the functional damage depend very much on the dose distribution in the large bowel, however, this influence is different for structural and for functional damage expression. Much less field size effect was seen for the structural damage of ulceration than for the functional damage of rectal obstruction when the length of whole circumference irradiation was reduced or when only half of the circumference was irradiated.
Different criteria are likely to apply for different types of damage even in one particular organ. The volume or the proportion of an organ which receives the target dose is not always a useful criterium for optimizing treatment plans.
研究大鼠大肠慢性辐射损伤的结构和功能依赖性，以便制定优化治疗计划的标准。
对大鼠直肠的不同体积进行局部照射。通过临床观察、直肠镜检查和组织病理学确定由此产生的慢性损伤。
结构损伤和功能损伤在很大程度上取决于大肠内的剂量分布，然而，这种影响在结构损伤和功能损伤表现方面有所不同。当全周照射长度减少或仅照射半周时，溃疡的结构损伤比直肠梗阻的功能损伤观察到的射野大小效应要小得多。
即使在一个特定器官中，不同类型的损伤可能适用不同的标准。接受靶剂量的器官体积或比例并不总是优化治疗计划的有用标准。
