Bischof M, Major J, Christ G, Becker G, Schlattinger B, Nüsslin F
Abteilung für Medizinische Physik, Radiologische Universitätsklinik Tübingen.
Strahlenther Onkol. 1995 Jun;171(6):340-7.
Circular collimated X-ray beams rotated in various non-coplanar planes as commonly used in stereotactic linac-based radiotherapy are generating spherical dose distributions with typically steep dose gradients. In case of irregular, especially elongated lesions, this technique fails to conform the shape of the corresponding planning target volume, and a collimator aperture has to be selected which allows for an acceptable dose distribution only on the expense of an excess dose to a larger amount of normal tissue. Therefore we have investigated a bicentric irradiation technique with sequentially treating an elongated target volume over two separated isocenters.
For the computer simulation studies we used the planning system of the stereotactic unit SRS-200 by Philips. Selected combinations of different collimator aperture were examined systematically by varying the distance between the two isocenters. Dose distributions for a specially developed head-phantom were calculated and analysed.
Optimization tables were generated taking into account the geometric quality criteria as well as the corresponding dose maxima. For a given size of the target volume, the appropriate parameters for the bicentric radiation treatment can be chosen. The calculated dose distributions turned out to be independent of the positioning of the two isocenters within the phantom.
The optimization tables serve to select a set of starting values for the interactive planning process of an elongated target volume resulting in a significant decrease of the overall time for treatment planning of irregular shaped lesions.
在基于直线加速器的立体定向放射治疗中常用的圆形准直X射线束在各种非共面平面中旋转,会产生具有典型陡峭剂量梯度的球形剂量分布。对于不规则病变,尤其是狭长病变,这种技术无法使剂量分布与相应的计划靶区形状相符,必须选择准直器孔径,这只能以对大量正常组织造成过量剂量为代价,来获得可接受的剂量分布。因此,我们研究了一种双中心照射技术,通过在两个分开的等中心依次治疗狭长的靶区。
在计算机模拟研究中,我们使用了飞利浦公司立体定向单元SRS - 200的计划系统。通过改变两个等中心之间的距离,系统地研究了不同准直器孔径的选定组合。计算并分析了专门开发的头部模型的剂量分布。
生成了考虑几何质量标准以及相应剂量最大值的优化表。对于给定大小的靶区,可以选择双中心放射治疗的合适参数。计算出的剂量分布结果与模型中两个等中心的位置无关。
优化表有助于为狭长靶区的交互式计划过程选择一组起始值,从而显著减少不规则形状病变治疗计划的总体时间。