Kryzhanovskiĭ G N, Krupina N A, Kucherianu V G
Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 Mar-Apr;45(2):377-87.
Dynamics of appearance and maintenance of emotional-behavioural disorders in male Wistar rats was studied on and after repeated neurotoxin MPTP injection at a dose of 15 mg/kg intraperitoneally daily for 18 days MPTP caused suppression of locomotion and rearing in open field test, decrease of daily liquid consumption and lowering of preference for the sucrose over water, increase of immobility time and depression index simultaneously with disadaptation in forced swimming test. Behavioural alterations were maintained for not less than a week after abolition of MPTP injection. Data improved the appearance and development of the state of decreased motivation simultaneously with anhedonia and behavioural despair in rats in response to MPTP injection. The state can be considered as a new model of DA-depended depression-like syndrome in rats.
研究了雄性Wistar大鼠在每日腹腔注射15mg/kg剂量的神经毒素MPTP，持续18天后及之后情感行为障碍的出现和维持动态。MPTP在旷场试验中导致运动和竖毛行为受抑制，每日液体摄入量减少，蔗糖相对于水的偏好降低，不动时间和抑郁指数增加，同时在强迫游泳试验中出现适应不良。在停止注射MPTP后，行为改变持续不少于一周。数据提示，MPTP注射后大鼠出现动机减退状态，同时伴有快感缺失和行为绝望，这种状态可被视为大鼠多巴胺依赖型抑郁样综合征的一种新模型。
