Lefebvre C, Lambert M, Pirson Y
Département de Médecine Interne, Cliniques Universitaires St-Luc, Bruxelles.
Acta Clin Belg. 1995;50(2):94-102. doi: 10.1080/17843286.1995.11718429.
The pulmonary-renal syndrome is defined by the association of alveolar hemorrhage and rapidly progressive glomerulonephritis. Goodpasture syndrome and necrotizing vasculitides are the most frequent causes. New serologic markers are currently more rapidly available (anti-glomerular basement membrane--anti-GBM--and antineutrophil cytoplasmic antibodies -ANCA), allowing clinicians to identify and distinguish these 2 entities, and to hasten the initiation of a pulse therapy, now well standardized, which improves the outcome of patients. However, these 2 serologic markers have limitations so that clinical assessment and renal biopsy remains essential in the diagnosis of pulmonary-renal syndrome. The authors propose an algorithmic approach for those confronted with such a condition.
肺肾综合征的定义是肺泡出血与快速进展性肾小球肾炎并存。Goodpasture综合征和坏死性血管炎是最常见的病因。目前新的血清学标志物（抗肾小球基底膜抗体——抗GBM——和抗中性粒细胞胞浆抗体——ANCA）能更快获得，这使临床医生能够识别和区分这两种疾病，并加快启动目前已标准化的冲击疗法，从而改善患者的预后。然而，这两种血清学标志物存在局限性，因此临床评估和肾活检在肺肾综合征的诊断中仍然至关重要。作者为面临这种情况的人提出了一种算法方法。
