蓝斑损毁及利血平处理对大鼠阿片类身体依赖性的影响。
Influences of locus coeruleus lesions and reserpine treatment on opioid physical dependence in rats.
作者信息
Miao H, Qin B Y
机构信息
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, China.
出版信息
Zhongguo Yao Li Xue Bao. 1995 Mar;16(2):137-40.
AIM
To study the role of locus coeruleus (LC) noradrenergic neurons in the opioid dependence.
METHODS
Chemical lesion of LC was produced by 6-hydroxydopamine (4 micrograms in 1 microL). Reserpine (Res) was used to deplete central noradrenaline. Composite scores of naloxone (4 mg.kg-1, ip) precipitated abstinence syndromes were calculated and the magnitude of weight loss was determined in chronic morphine (Mor)- or dihydroetorphine (DHE)-treated rats.
RESULTS
Lesions of LC made Mor, but not DHE, abstinence syndrome more serious. Multiple doses of Res (0.5 mg.kg-1.d-1 x 3 d) increased scores of Mor and DHE abstinence syndrome, made worse the loss of body weight in chronic Mor-, but not DHE-, treated rats. A single dose of Res (0.5 mg.kg-1) speeded up the development of physical dependence on Mor.
CONCLUSION
The LC noradrenergic neurons play a role in suppression of some withdrawal symptoms.
目的
研究蓝斑（LC）去甲肾上腺素能神经元在阿片类药物依赖中的作用。
方法
用6-羟基多巴胺（4微克溶于1微升）对LC进行化学损毁。利血平（Res）用于耗尽中枢去甲肾上腺素。计算纳洛酮（4毫克·千克-1，腹腔注射）诱发的戒断综合征的综合评分，并测定慢性吗啡（Mor）或二氢埃托啡（DHE）处理大鼠的体重减轻幅度。
结果
损毁LC使Mor而非DHE的戒断综合征更严重。多次给予Res（0.5毫克·千克-1·天-1×3天）增加了Mor和DHE戒断综合征的评分，使慢性Mor处理而非DHE处理大鼠的体重减轻更严重。单次给予Res（0.5毫克·千克-1）加速了对Mor身体依赖的发展。
结论
LC去甲肾上腺素能神经元在抑制某些戒断症状中起作用。
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