Bos C, Hoofd L, Turek Z
Department of Physiology, University of Nijmegen, The Netherlands.
Adv Exp Med Biol. 1994;361:1-6. doi: 10.1007/978-1-4615-1875-4_1.
Aroesty and Gross investigated the effect of mixing in gaps between two successive RBCs on the local mass transfer at the capillary wall. They found that the effect was insignificant. In this presentation it is shown that their conclusion results from their choice of boundary conditions. When boundary concentrations are chosen which are more similar to those in diffusional models the flux at the capillary wall increases significantly when mixing increases. The calculations presented indicate that mixing of plasma may enhance oxygen transport, although it is impossible to assess the physiological importance. To be able to investigate that, a model has to be developed that includes oxygen transport in both the RBCs and tissue, the oxygen release in the RBCs, and the oxygen consumption in the tissue.
阿罗斯蒂和格罗斯研究了两个连续红细胞之间间隙中的混合对毛细血管壁局部传质的影响。他们发现这种影响微不足道。在本报告中表明，他们的结论源于他们对边界条件的选择。当选择与扩散模型中更相似的边界浓度时，随着混合增加，毛细血管壁处的通量会显著增加。所给出的计算表明，血浆混合可能会增强氧气运输，尽管无法评估其生理重要性。为了能够对此进行研究，必须开发一个模型，该模型要包括红细胞和组织中的氧气运输、红细胞中的氧气释放以及组织中的氧气消耗。
