Benaron D A, Ho D C, Spilman S, Van Houten J P, Stevenson D K
Medical Imaging and Spectroscopy Section, Stanford School of Medicine, Palo Alto, CA, USA.
Adv Exp Med Biol. 1994;361:215-22. doi: 10.1007/978-1-4615-1875-4_27.
Optical imaging has been used to image phantoms, animals, and humans. It offers the potential for the production of functional images of tissues, such as oxygenation of brain during stroke. Fast algorithms are needed to allow diagnostically useful images to be generated under realistic conditions, including the likelihood that transmission geometries will not be possible. We proposed a linear algorithm, while less than ideal, may allow rapid reconstruction of images and avoid the pitfalls of recursive, nonlinear solutions. Such techniques may also facilitate the use of varied but physiologic imaging geometries. We found that linear backprojection tomography is feasible for clinical use. Conversion of the present mechanically scanning device to a clinical scanner should be possible with retention of the current processing algorithms. Such a clinical scanner should ultimately be able to generate images in less than one minute with centimeter resolution at the center of living human brain.
光学成像已被用于对模型、动物和人体进行成像。它具有生成组织功能图像的潜力，比如中风期间大脑的氧合情况。需要快速算法以便在实际条件下生成具有诊断价值的图像，包括可能无法采用透射几何结构的情况。我们提出了一种线性算法，虽然并非理想算法，但可能允许快速重建图像，并避免递归非线性解决方案的缺陷。此类技术还可能便于使用各种不同但符合生理状况的成像几何结构。我们发现线性反投影断层扫描在临床上是可行的。将目前的机械扫描设备转换为临床扫描仪，同时保留当前的处理算法应该是可行的。这样一台临床扫描仪最终应该能够在不到一分钟的时间内，在活体人类大脑中心生成厘米级分辨率的图像。
