心肌梗死的遗传决定因素。

Genetic determinants of myocardial infarction.

作者信息

Breslow J L, Dammerman M

机构信息

Laboratory of Biochemical Genetics and Metabolism, Rockefellow University, New York, NY 10021, USA.

出版信息

Adv Exp Med Biol. 1995;369:65-78. doi: 10.1007/978-1-4615-1957-7_7.

DOI:10.1007/978-1-4615-1957-7_7

PMID:7598017

Abstract

There is a strong familial and genetic nature of CAD and predisposing metabolic disorders. This should encourage health care workers to focus additional attention on the younger members of affected families, particularly the families of patients with MI prior to age 55. This should take the form of genetic counseling as well as patient education and follow-up with respect to hygienic measures of proven efficacy, and aggressive treatment of metabolic disorders that prove resistant to changes in lifestyle. In certain cases, as discussed in this review, genetic testing may prove helpful.

摘要

CAD（冠状动脉疾病）和易患代谢紊乱具有很强的家族性和遗传性。这应促使医护人员将更多注意力集中在受影响家庭的年轻成员身上，尤其是55岁之前发生心肌梗死患者的家庭。这应以遗传咨询、患者教育以及对已证实有效的卫生措施的随访，以及对经证实对生活方式改变有抵抗的代谢紊乱进行积极治疗的形式进行。在某些情况下，如本综述中所讨论的，基因检测可能会有所帮助。