Peracchia A, Sarli L, Pietra N, Cattaneo G, Thenasseril B
Istituto di Clinica Chirurgica Generale e Terapia Chirurgica, Università degli Studi di Parma.
Ann Ital Chir. 1994 Nov-Dec;65(6):691-7.
At the moment of surgical intervention, colorectal cancer involves adjacent tissues or organs in a percentage of cases ranging between 5% and 12%. "En bloc" resection of these tumors, when not associated with distant metastasis, allows survival at 5 years in from 32% to 79% of cases. The authors discuss their personal experience on the subject of extended resection for carcinoma of the large intestine, in order to evaluate not only the possible anatomico-clinical peculiarities but also both short and long term results. In the period from 1976 to 1993 1164 patients underwent surgery for colorectal cancer, in 791 cases (68%) with a curative aim. 71 patients underwent extended resection, in 59 cases for the curative treatment of a primary tumor and in 12 for the treatment of a local recurrence (LR). Pathologic examination revealed neoplastic infiltration into at least one of the organs removed with the tumor in 43 cases (61%). It must, however, be pointed out that the above frequency was considerably higher (92%) when extended resection was carried out for LR than in cases of exeresis of primary cancers (54%). The reported results show that extended resection leads to potentially higher morbidity and mortality than can be observed after standard resection, but that, at the same time, it proves to be the only treatment able to provide these patients with good prospects for fairly long-term survival. Recourse to this procedure must therefore always be out of necessity, furthermore the extension of demolition must be adapted to the operative finding.(ABSTRACT TRUNCATED AT 250 WORDS)
在进行手术干预时,一定比例(5%至12%)的结直肠癌会累及相邻组织或器官。对于这些肿瘤,在无远处转移的情况下进行“整块”切除,32%至79%的患者可存活5年。作者讨论了他们在大肠肿瘤扩大切除术方面的个人经验,目的不仅是评估可能的解剖临床特点,还有短期和长期结果。在1976年至1993年期间,1164例患者接受了结直肠癌手术,其中791例(68%)以治愈为目的。71例患者接受了扩大切除术,59例用于原发性肿瘤的根治性治疗,12例用于局部复发(LR)的治疗。病理检查显示,43例(61%)患者的肿瘤切除标本中至少有一个器官有肿瘤浸润。然而,必须指出的是,对LR进行扩大切除术时上述发生率(92%)远高于原发性癌切除病例(54%)。报告结果表明,扩大切除术导致的发病率和死亡率可能高于标准切除术,但同时,它被证明是唯一能为这些患者提供相当长期良好生存前景的治疗方法。因此,采用这种手术必须始终出于必要,此外,切除范围必须根据手术所见进行调整。(摘要截选至250字)