Mpabalwani M, Oshitani H, Kasolo F, Mizuta K, Luo N, Matsubayashi N, Bhat G, Suzuki H, Numazaki Y
Virology Laboratory, University Teaching Hospital, Lusaka, Zambia.
Ann Trop Paediatr. 1995;15(1):39-43. doi: 10.1080/02724936.1995.11747747.
The clinical and epidemiological aspects of rotavirus diarrhoea were studied in hospitalized children with acute diarrhoea in Lusaka, Zambia. Two hundred and fifty-six (24.0%) of 1069 children admitted to the study were shedding rotavirus. The rotavirus-positive rate was highest in children less than 1 year of age (37.0%) and it was also high in those less than 6 months old. Rotavirus diarrhoea was seen throughout the year with a higher rotavirus-positive rate in the dry season. In rotavirus-positive diarrhoea patients, more children were dehydrated (82.4%) than in the rotavirus-negative group (56.2%). Rotavirus infection was more common in the children with normal nutritional status (27.6%, 162/588) than in those with malnutrition (19.3%, 93/482). The associated case fatality rate in the rotavirus-positive group was 6.4%, significantly less than in the rotavirus-negative group (OR 0.44, 95% CI 0.24-0.79), and mortality cases were seen only in children less than 2 years old.
在赞比亚卢萨卡，对住院的急性腹泻儿童的轮状病毒腹泻的临床和流行病学特征进行了研究。1069名参与研究的儿童中，有256名（24.0%）排出轮状病毒。轮状病毒阳性率在1岁以下儿童中最高（37.0%），在6个月以下儿童中也很高。全年均可见轮状病毒腹泻，旱季的轮状病毒阳性率更高。在轮状病毒阳性腹泻患者中，脱水的儿童（82.4%）比轮状病毒阴性组（56.2%）更多。轮状病毒感染在营养状况正常的儿童中（27.6%，162/588）比在营养不良的儿童中（19.3%，93/482）更常见。轮状病毒阳性组的相关病死率为6.4%，显著低于轮状病毒阴性组（比值比0.44，95%可信区间0.24 - 0.79），且死亡病例仅见于2岁以下儿童。
