Lee Way S, Rajasekaran Ganeswrie, Pee Susan, Karunakaran Rina, Hassan Hamimah H, Puthucheary Savithri D
Department of Paediatrics, University of Malaya Medical Center, Kuala Lumpur, Malaysia.
J Paediatr Child Health. 2006 Sep;42(9):509-14. doi: 10.1111/j.1440-1754.2006.00913.x.
To study the role of rotavirus in children hospitalised for acute gastroenteritis (AGE) in two urban hospitals in Malaysia.
A 12-month prospective study (January to December 2002), in children younger than 14 years with AGE hospitalised to the paediatric units of University of Malaya Medical Centre (UMMC), Kuala Lumpur; and Hospital Sultanah Aminah (HSA), Johor Bahru, Malaysia was conducted.
In 2002, 399 and 1307 children with AGE were admitted to UMMC and HSA, respectively. Two hundred and eighty-eight (72%) stool samples from UMMC and 901 (69%) samples from HSA were analysed. Rotavirus was the most common aetiological agent identified in both centres (average 32%; UMMC 35%, HSA 30%, P = 0.94). The peak age group for rotavirus-related hospitalisation was 24-35 months for UMMC and 12-23 months for HSA. Nine percent of patients hospitalised for rotavirus infection in UMMC and 22% of patients in HSA were older than 5 years of age. An outbreak of rotavirus infection within the communities served by both centres resulting in an increase in hospital admissions of rotavirus gastroenteritis was observed in both units from January to March 2002.
The peak age group for rotavirus-related hospital admission in this study was much older, between 12 to 35 months. It is uncertain whether this was related to the outbreak of rotavirus gastroenteritis observed within two urban areas from January to March 2002 causing re-infection with rotavirus in older children.
研究轮状病毒在马来西亚两家城市医院因急性胃肠炎（AGE）住院儿童中的作用。
进行了一项为期12个月的前瞻性研究（2002年1月至12月），研究对象为年龄小于14岁、因AGE入住马来西亚吉隆坡马来亚大学医学中心（UMMC）儿科病房以及柔佛州新山苏丹娜阿米娜医院（HSA）儿科病房的儿童。
2002年，分别有399名和1307名患AGE的儿童入住UMMC和HSA。对来自UMMC的288份（72%）粪便样本和来自HSA的901份（69%）样本进行了分析。轮状病毒是两个中心鉴定出的最常见病原体（平均32%；UMMC为35%，HSA为30%，P = 0.94）。UMMC轮状病毒相关住院的高峰年龄组为24 - 35个月，HSA为12 - 23个月。UMMC中因轮状病毒感染住院的患者有9%年龄大于5岁，HSA中这一比例为22%。2002年1月至3月，两个中心服务的社区均出现了轮状病毒感染暴发，导致轮状病毒性胃肠炎住院人数增加。
本研究中轮状病毒相关住院的高峰年龄组要大得多，在12至35个月之间。尚不确定这是否与2002年1月至3月在两个城市地区观察到的轮状病毒性胃肠炎暴发有关，该暴发导致大龄儿童再次感染轮状病毒。
