肌萎缩侧索硬化症的分子研究方法
Molecular approaches to amyotrophic lateral sclerosis.
作者信息
Smith R G, Appel S H
机构信息
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Annu Rev Med. 1995;46:133-45. doi: 10.1146/annurev.med.46.1.133.
PMID:7598450
Abstract
New discoveries are expanding our knowledge of mechanisms involved in amyotrophic lateral sclerosis (ALS) pathogenesis. Some recent advances in our understanding of motoneuron death in familial ALS (fALS) and sporadic ALS (sALS) are reviewed, with emphasis on molecular similarities that may further unite these phenotypically linked diseases.
摘要
新的发现正在扩展我们对肌萎缩侧索硬化症（ALS）发病机制相关机制的认识。本文综述了我们在家族性ALS（fALS）和散发性ALS（sALS）运动神经元死亡理解方面的一些最新进展，重点关注可能进一步将这些表型相关疾病联系起来的分子相似性。
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