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Nucleotide-selective cleavage of duplex DNA by nitric oxide.

作者信息

Sugiura Y, Matsumoto T

机构信息

Institute for Chemical Research, Kyoto University, Japan.

出版信息

Biochem Biophys Res Commun. 1995 Jun 26;211(3):748-53. doi: 10.1006/bbrc.1995.1876.

DOI:10.1006/bbrc.1995.1876
PMID:7598702
Abstract

In the presence of sodium nitrite and sodium hydrosulfite, the produced NO has been confirmed by the detection of bleomycin-Fe(II)-NO adduct complex. Nitric oxide clearly induces DNA form change of form I-->forms II & III. Of special interest is the fact that (1) NO attacks guanine bases as the most preferential cleaving sites and (2) the frequency of the NO-induced cutting decreases in the order G > C > A > T. The preferred cleavage at GC sequences by NO may correlate to predominant mutagenicity at GC sites by nitric oxide.

摘要

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