Lukacs N W, Strieter R M, Kunkel S L
Department of Pathology, University of Michigan Medical School, Ann Arbor, USA.
Am J Respir Cell Mol Biol. 1995 Jul;13(1):1-6. doi: 10.1165/ajrcmb.13.1.7598934.
The pathologic manifestation of an allergic airway response is a culmination of several coordinated events involving the participation of multiple mechanisms and cell types. The early release of mast cell-derived arachidonic acid metabolites, production of early-response cytokines, and increased expression of adhesion molecules and production of chemokines all lead to the recruitment of multiple cell types with the ability to participate in the allergic airway response. The coordinated use of animal models related to clinical observations will allow further elucidation of the mechanisms involved in the initiation, maintenance, and regulation of allergic airway inflammation leading to airway damage.
过敏性气道反应的病理表现是一系列协调事件的结果，涉及多种机制和细胞类型的参与。肥大细胞衍生的花生四烯酸代谢产物的早期释放、早期反应细胞因子的产生、黏附分子表达的增加以及趋化因子的产生，都导致多种具有参与过敏性气道反应能力的细胞类型的募集。将与临床观察相关的动物模型进行协同应用，将有助于进一步阐明导致气道损伤的过敏性气道炎症的起始、维持和调节所涉及的机制。
