Höffkes H G, Schumann A, Uppenkamp M, Teschendorf C, Schindler A E, Parwaresch R, Brittinger G
Division of Hematology, Department of Medicine, University of Essen, Germany.
Ann Hematol. 1995 May;70(5):273-6. doi: 10.1007/BF01784047.
The genital tract as primary site of malignant non-Hodgkin's lymphoma in women is extremely rare, whereas secondary involvement in advanced disease is found in about 40% of cases. In this report a patient is presented who had a primary vaginal non-Hodgkin's lymphoma of the centroblastic type according to the Kiel classification, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free disease for 3 years. A review of the literature shows that favorable prognosis of localized disease seems to be a common experience. Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women cytotoxic chemotherapy should be considered to preserve fertility.
女性生殖道作为原发性恶性非霍奇金淋巴瘤的部位极为罕见，而在晚期疾病中约40%的病例会出现继发性累及。本报告介绍了一名患者，根据基尔分类，其患有原发性阴道中心母细胞型非霍奇金淋巴瘤，对细胞毒性化疗（CHOP）反应良好，无病生存3年。文献回顾表明，局限性疾病预后良好似乎是一种常见情况。阴道原发性累及可通过盆腔放疗成功治疗，但对于年轻女性，应考虑细胞毒性化疗以保留生育能力。
