Korbut R, Marcinkiewicz E, Cieślik K, Gryglewski R J
Department of Pharmacology, Medical College of Jagiellonian University, Cracow, Poland.
J Physiol Pharmacol. 1995 Mar;46(1):37-44.
Here we describe effects of four nitric oxide (NO) donors, 4-arylsubstituted oxatriazol derivatives and 3-morpholino-sydnonimine (SIN-1) at concentrations of 30-1000 microM on the release of plasminogen activator inhibitor (PAI) from rabbit platelets in vitro. At 37 degrees C, pH of 7.4 and a concentration of 30 microM, all compounds released NO as measured by the Werringloer's technique. The NO-generating potency of the compounds correlated with their capacity to inhibit the release of PAI from platelets and both phenomena were concentration-dependent. We conclude that various types of NO-donors activate plasma fibrinolytic system through inhibition of the release of PAI from platelets.
在此，我们描述了四种一氧化氮（NO）供体、4-芳基取代的氧杂三唑衍生物和3-吗啉代西多胺（SIN-1）在30 - 1000微摩尔浓度下对兔血小板体外纤溶酶原激活物抑制剂（PAI）释放的影响。在37摄氏度、pH值为7.4且浓度为30微摩尔时，通过韦林格勒技术测定，所有化合物均释放出NO。这些化合物产生NO的能力与其抑制血小板释放PAI的能力相关，且这两种现象均呈浓度依赖性。我们得出结论，各类NO供体通过抑制血小板释放PAI来激活血浆纤维蛋白溶解系统。
