Testa R, Picciotto A, Lapertosa G, Caglieris S, Risso D, Borzone S, Campo N, Alvarez S, Varagona G, Lantieri P B
Dipartimento di Medicina Interna, Università di Genova, Italy.
Ital J Gastroenterol. 1994 Dec;26(9):437-41.
Eighty-one patients with HCV positive chronic active hepatitis (CAH) were studied to correlate, in multivariate regression analysis, liver tests with the histological activity index (HAI). The median HAI value (9.4) divided the patients into two groups; 44 under the 9.4 value (moderate CAH) and 37 above (severe CAH). Multiple regression improved the significance of nine biochemical parameters related to HAI in univariate analysis, and backward stepwise analysis identified the combination of alanine-aminotransferase (ALT), gammaglobulins (gamma GL), gammaglutamyl transpeptidase (gamma GT) and prolyl-hydroxylase (PH) as the best relationship with HAI (R = 0.520, p < 0.0001). A biochemical activity index (BAI) calculated as: 2.304 + ALT x 0.013 + gamma GL x 1.76 + gamma GT x 0.008 + PH x 0.012 showed the higher significant difference between moderate (7.7 +/- 1.3) and severe (12.2 +/- 2) CAH (p < 0.0001). These results suggest that this BAI could be a pointer for checking activity of chronic liver diseases.
对81例丙型肝炎病毒（HCV）阳性的慢性活动性肝炎（CAH）患者进行了研究，以便在多变量回归分析中将肝功能检查结果与组织学活动指数（HAI）进行关联。HAI的中位数（9.4）将患者分为两组；HAI值低于9.4的44例（中度CAH）和高于9.4的37例（重度CAH）。多变量回归提高了单变量分析中与HAI相关的9个生化参数的显著性，向后逐步分析确定丙氨酸转氨酶（ALT）、γ球蛋白（γGL）、γ-谷氨酰转肽酶（γGT）和脯氨酰羟化酶（PH）的组合与HAI的关系最为密切（R = 0.520，p < 0.0001）。以2.304 + ALT×0.013 + γGL×1.76 + γGT×0.008 + PH×0.012计算的生化活动指数（BAI）显示，中度（7.7±1.3）和重度（12.2±2）CAH之间存在高度显著差异（p < 0.0001）。这些结果表明，该BAI可能是检查慢性肝病活动情况的一个指标。
