Iyengar V, Chou P P, Costantino A G, Cook C B
Department of Pathology, Fairfax Hospital, Fall Church, Virginia 22046, USA.
J Trace Elem Electrolytes Health Dis. 1994 Dec;8(3-4):213-5.
Random samples of urine from control subjects, and subjects treated with methadone (an agonist of morphine) for drug addiction, were analyzed for calcium and trace elements zinc and copper. The following differences (based on creatinine) were observed between the two groups: Calcium excretion did not show any significant differences between the two groups (146 mmg/g creatinine vs. 135 mg/g creatinine vs. 33 +/- 3 micrograms/g creatinine in controls). However, the excretion of copper in drug addicts diminished (23 +/- 3 micrograms/g creatinine in controls; p < 0.05), while that of zinc was excessive (600 +/- 50 micrograms/g creatinine vs. 300 +/- 30 micrograms/g creatinine in controls; p < 0.001). The ever increasing link between zinc and immunity and the fact that drug addicts are susceptible to various infections such as hepatitis and acquired immuno deficiency syndrome raises concern about the excessive urinary loss of zinc in this group and calls for further investigations such as balance studies and intervention if necessary.
对来自对照组受试者以及接受美沙酮（一种吗啡激动剂）治疗的药物成瘾受试者的随机尿液样本进行了钙以及微量元素锌和铜的分析。在两组之间观察到以下基于肌酐的差异：两组之间钙排泄未显示任何显著差异（对照组为146毫克/克肌酐、135毫克/克肌酐和33±3微克/克肌酐）。然而，药物成瘾者的铜排泄减少（对照组为23±3微克/克肌酐；p<0.05），而锌排泄过多（对照组为600±50微克/克肌酐，药物成瘾者为300±30微克/克肌酐；p<0.001）。锌与免疫之间日益紧密的联系以及药物成瘾者易患各种感染（如肝炎和获得性免疫缺陷综合征）这一事实，引发了对该组人群锌尿流失过多的担忧，并呼吁进行进一步研究，如平衡研究，必要时进行干预。
