Alisoglu R M, Nagelhout J, Kyff J V, Perov S, Santoro P W, Scarsella J
CRNA. 1995 Feb;6(1):43-5.
Pipecuronium Bromide (Arduan, Organon, Inc, West Orange) is a long-acting, nondepolarizing neuromuscular blocking agent. The efficacy of pyridostigmine 170 micrograms/kg intravenously (approximately 10 mg/70 kg) for reversing pipecuronium has not been reported. This study was performed to determine the time required to obtain a train-of-four (TOF) ratio of 0.7 after administration of pyridostigmine 140 micrograms/kg at 25% recovery of T1 after pipecuronium-induced neuromuscular blockade. Sixteen, American Society of Anesthesiology (ASA) I or II patients undergoing surgical procedures of at least 90 minutes, requiring intubation and muscle relaxation were included. Neuromuscular blockade was assessed using the Puritan-Bennett/Datex NMT 221 placed for ulnar nerve stimulation. Anesthesia was maintained with a nitrous oxide/narcotic technique and the use of potent inhalational anesthetics was avoided. The mean reversal time was found to be 16.14 minutes, with a minimum of 10.3 minutes and a maximum of 24.3 minutes. The standard error was +/- 1.05 minutes with a variance of 17.68 minutes.
哌库溴铵（阿端，奥加农公司，西奥兰治）是一种长效非去极化型神经肌肉阻滞剂。静脉注射170微克/千克的吡啶斯的明（约10毫克/70千克）用于拮抗哌库溴铵的效果尚未见报道。本研究旨在确定在哌库溴铵诱导的神经肌肉阻滞恢复至T1的25%时，静脉注射140微克/千克的吡啶斯的明后，获得四个成串刺激（TOF）比值为0.7所需的时间。纳入了16例美国麻醉医师协会（ASA）I或II级、接受至少90分钟手术、需要插管和肌肉松弛的患者。使用置于尺神经用于刺激的Puritan-Bennett/Datex NMT 221评估神经肌肉阻滞。采用氧化亚氮/麻醉性镇痛药技术维持麻醉，避免使用强效吸入麻醉药。发现平均恢复时间为16.14分钟，最短为10.3分钟，最长为24.3分钟。标准误为±1.05分钟，方差为17.68分钟。
