Turjanski N, Weeks R, Dolan R, Harding A E, Brooks D J
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
Brain. 1995 Jun;118 ( Pt 3):689-96. doi: 10.1093/brain/118.3.689.
We have used PET to study striatal D1 and D2 receptor binding in 10 patients with either the choreic or akinetic-rigid variants of Huntington's disease and in three patients with other causes of chorea. Background rigidity and bradykinesia in choreic patients were scored with a four-point scale. PET studies showed a severe and parallel reduction of both striatal D1 and D2 receptor binding in Huntington's disease patients irrespective of their predominant phenotype (mean reduction 60%). Huntington's disease patients with rigidity showed more pronounced reduction of striatal D1 and D2 binding compared with those without rigidity. A case of chorea associated with systemic lupus erythematosus had normal D2 binding. These results suggest that the presence of chorea per se may not be determined by alterations in striatal dopamine receptor binding, but that rigidity in Huntington's disease is associated with severe striatal D1 and D2 receptor loss.
我们利用正电子发射断层扫描（PET）研究了10例患有亨廷顿舞蹈病的舞蹈症或运动不能-强直型变体患者以及3例因其他病因导致舞蹈症患者的纹状体D1和D2受体结合情况。对舞蹈症患者的背景性强直和运动迟缓采用四点量表进行评分。PET研究显示，亨廷顿舞蹈病患者的纹状体D1和D2受体结合均严重且平行降低，无论其主要表型如何（平均降低60%）。与无强直症状的患者相比，伴有强直症状的亨廷顿舞蹈病患者纹状体D1和D2结合的降低更为明显。1例与系统性红斑狼疮相关的舞蹈症患者D2结合正常。这些结果表明，舞蹈症本身的存在可能并非由纹状体多巴胺受体结合的改变所决定，但亨廷顿舞蹈病中的强直与纹状体D1和D2受体的严重丧失有关。
