Rothblat D S, Schneider J S
Department of Neurology, Hahnemann University School of Medicine, Philadelphia, PA 19102, USA.
Neurodegeneration. 1995 Mar;4(1):87-92. doi: 10.1006/neur.1995.0010.
The effects of additional MPTP injections on striatal neurochemistry and tyrosine hydroxylase positive cell populations within the ventral mesencephalon in cats recovered from parkinson-like motor deficits resulting from previous MPTP administration was studied. A second or third series of MPTP injections in recovered cats initially reinstated parkinson-like motor deficits. All cats again recovered normalized motor function two to three weeks after MPTP administration. Neurochemical analysis of striatal tissue showed no or only minor differences in dopamine and metabolite levels within most striatal regions sampled between cats which received single or multiple sets of MPTP injections. Cell count results showed no significant differences between the two MPTP conditions for the majority of the regions studied. These results suggest that the mechanisms responsible for motor recovery from MPTP intoxication in cats can be transiently disrupted by further exposure to MPTP and that cats do not develop a permanent parkinsonian syndrome from repeated MPTP exposure.
研究了额外注射MPTP对猫纹状体神经化学和腹侧中脑酪氨酸羟化酶阳性细胞群的影响，这些猫之前因注射MPTP出现类似帕金森病的运动功能缺陷后已恢复。对恢复后的猫进行第二或第三次MPTP注射，最初会再次引发类似帕金森病的运动功能缺陷。所有猫在注射MPTP后两到三周再次恢复正常运动功能。对纹状体组织的神经化学分析表明，在接受单次或多次MPTP注射的猫所采样的大多数纹状体区域中，多巴胺和代谢物水平没有差异或只有微小差异。细胞计数结果显示，在大多数研究区域，两种MPTP处理条件之间没有显著差异。这些结果表明，猫从MPTP中毒中恢复运动功能的机制可能会因进一步接触MPTP而暂时中断，并且猫不会因反复接触MPTP而发展为永久性帕金森综合征。
