Pruitt J H, Copeland E M, Moldawer L L
Shock. 1995 Apr;3(4):235-51. doi: 10.1097/00024382-199504000-00001.
Interleukin-1 (IL-1) is one of several proinflammatory cytokines produced during infection, sepsis, and the systemic inflammatory response syndrome (SIRS) that serves to initiate the host inflammatory response and to integrate nonspecific immunity. Many of IL-1's biologic effects are beneficial to the host in times of stress, but when produced for extended periods of time or in excessive quantities, IL-1 contributes to morbidity and mortality. In fact, excessive IL-1 production has been directly linked to the development of hypotension, shock, multi-organ system failure, hematologic dyscrasia, and death in patients and animals with sepsis, SIRS, and septic shock. Recent research interest has focused on IL-1 inhibition to improve outcome in sepsis and septic shock. This article will review the role for IL-1 in sepsis and septic shock, and the function and status of the IL-1 receptors and IL-1 receptor antagonist in modulating IL-1 actions. The results of investigations of IL-1 inhibition in animal models and in human subjects with sepsis and septic shock will also be reviewed.
白细胞介素-1（IL-1）是在感染、脓毒症和全身炎症反应综合征（SIRS）期间产生的几种促炎细胞因子之一，其作用是启动宿主炎症反应并整合非特异性免疫。在应激状态下，IL-1的许多生物学效应对宿主有益，但如果长时间产生或产生过量，IL-1会导致发病和死亡。事实上，在患有脓毒症、SIRS和感染性休克的患者及动物中，IL-1的过量产生与低血压、休克、多器官系统衰竭、血液系统异常及死亡的发生直接相关。最近的研究兴趣集中在抑制IL-1以改善脓毒症和感染性休克的预后。本文将综述IL-1在脓毒症和感染性休克中的作用，以及IL-1受体和IL-1受体拮抗剂在调节IL-1作用方面的功能和状态。还将综述在动物模型以及患有脓毒症和感染性休克的人类受试者中抑制IL-1的研究结果。
