Scheuplein R J
Weinberg Consulting Group Inc., Washington, DC 20036-2400, USA.
Cancer Lett. 1995 Jun 29;93(1):103-12. doi: 10.1016/0304-3835(95)03791-T.
Significantly more willingness to depart from worst case assumptions in the evaluation of carcinogenic risk has developed in the last 30 years. Scientists within regulatory agencies and in the academic community are reaching a consensus on the inadequacy of current test methods and on the need for more mechanistic data to help interpret the carcinogen bioassay. The slow regulatory acceptance of the concept of 'secondary mechanism' in the evaluation of cancer risk from chemicals in the U.S. is illustrated by a chronology of laws, policies, and consensus scientific positions adopted through the years.
在过去30年里，人们在评估致癌风险时，显著更愿意偏离最坏情况假设。监管机构和学术界的科学家们就当前测试方法的不足以及需要更多机制数据来帮助解释致癌物生物测定达成了共识。美国多年来通过的一系列法律、政策和共识性科学立场说明了监管机构对化学品癌症风险评估中“二级机制”概念的接受速度缓慢。
