啮齿动物膀胱肿瘤并不总能预测人类情况。

Rodent bladder tumors do not always predict for humans.

作者信息

Cohen S M, Lawson T A

机构信息

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135, USA.

出版信息

Cancer Lett. 1995 Jun 29;93(1):9-16. doi: 10.1016/0304-3835(95)03785-U.

DOI:10.1016/0304-3835(95)03785-U

PMID:7600547

Abstract

Dr. David Clayson, 20 years ago, suggested that chemicals which lead to the formation of calculi in rodents might pose an artifact with respect to extrapolation to potential carcinogenic risk to humans. We reviewed what has been learned about the role of calculi in urinary bladder carcinogenesis in the ensuing 20 years, along with several examples. Formation of microcrystalluria and amorphous precipitate also poses problems in interpretation and examples are described. The chemicals producing these solid urinary materials are non-genotoxic, with marked increase in cell proliferation being the mode of action by which they are able to produce cancer in long-term rodent bioassays.

摘要

大卫·克莱森博士在20年前就提出，导致啮齿动物形成结石的化学物质在推断对人类的潜在致癌风险方面可能存在人为因素。我们回顾了在随后的20年里关于结石在膀胱癌发生中的作用所学到的知识，并列举了几个例子。微晶尿和无定形沉淀物的形成在解释方面也存在问题，并对此进行了举例说明。产生这些尿液固体物质的化学物质是非基因毒性的，细胞增殖显著增加是它们在长期啮齿动物生物测定中能够致癌的作用方式。