钥孔血蓝蛋白含有与T抗原交叉反应的Gal(β1-3)-GalNAc决定簇。
Keyhole limpet hemocyanin contains Gal(beta 1-3)-GalNAc determinants that are cross-reactive with the T antigen.
作者信息
Wirguin I, Suturkova-Milosević L, Briani C, Latov N
机构信息
Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
出版信息
Cancer Immunol Immunother. 1995 May;40(5):307-10. doi: 10.1007/BF01519630.
Abstract
Keyhole limpet hemocyanin (KLH) is widely used as a carrier molecule to enhance immune responses to administered antigens, and for immunotherapy of bladder and renal carcinoma. In the present study we show, using lectin and antibody binding studies, that native KLH contains Gal(beta 1-3)GalNAc-bearing oligosaccharides, and that immunization with KLH in Lewis rats induces the production of anti-Gal(beta 1-3) GalNAc antibodies. This might explain the beneficial effect of KLH in bladder cancers that express cross-reactive Gal(beta 1-3)GalNAc determinants or the T antigen.
摘要
钥孔戚血蓝蛋白（KLH）被广泛用作载体分子，以增强对所给予抗原的免疫反应，并用于膀胱癌和肾癌的免疫治疗。在本研究中，我们通过凝集素和抗体结合研究表明，天然KLH含有带有Gal（β1-3）GalNAc的寡糖，并且在Lewis大鼠中用KLH免疫可诱导产生抗Gal（β1-3）GalNAc抗体。这可能解释了KLH在表达交叉反应性Gal（β1-3）GalNAc决定簇或T抗原的膀胱癌中的有益作用。
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