Ferluga D, Rott T, Rutar-Zupancic M
Prax Klin Pneumol. 1979 Jan;33(1):15-21.
Many investigations stress the importance of dysplastic changes of bronchial epithelium, chronic bronchitis, and chronic scar producing inflammatory processes of the lung in the development of bronchopulmonary carcinoma.--At the Institute for Lung Diseases and Tuberculosis Golnik in the period from 1964--1973 we found among 185 surgically resected lungs 20 cases (10,8%) of pulmonary scar cancer. In six patients (30,0%) we proved the tuberculous origin of the scar. Scar cancer was established in 18 patients (90,0%) in the upper parts of the lung. In half of all cases adenocarcinoma was found, squamous cell carcinoma was present in two cases and small cell anaplastic carcinoma in one case. --In the same period we found in surgically resected material two cases of tumourlets. In the first case in a 49-year old woman, the tumourlet was located in the scar surrounding an aspergillus mycetoma in the right upper pulmonary lobe. In the second case a tumourlet was found in a 42-year old woman in the region of focal fibrosis of the right upper pulmonary lobe. An 8 respectively 12 years postoperative follow-up shows no recurrence in both patients. This corresponds to the data from literature describing the tumourlet as benign process, recently reported as a minute peripheral carcinoid tumour.
许多研究强调支气管上皮发育异常变化、慢性支气管炎以及肺部慢性瘢痕形成性炎症过程在支气管肺癌发生中的重要性。——在戈尔尼克肺病与结核病研究所，1964年至1973年期间，我们在185例手术切除的肺中发现了20例（10.8%）肺瘢痕癌。在6例患者（30.0%）中，我们证实了瘢痕的结核起源。18例患者（90.0%）的瘢痕癌发生在肺上部。所有病例中有一半发现为腺癌，2例为鳞状细胞癌，1例为小细胞间变性癌。——同一时期，我们在手术切除的材料中发现了2例微瘤。第一例发生在一名49岁女性身上，微瘤位于右上肺叶曲菌球周围的瘢痕中。第二例在一名42岁女性的右上肺叶局灶性纤维化区域发现了一个微瘤。分别进行了8年和12年的术后随访，两名患者均未复发。这与文献中描述微瘤为良性过程的数据相符，最近有报道称其为微小外周类癌肿瘤。
