Bedri A, Abebe E
Department of Paediatrics and Child Health, Addis Abeba University.
Ethiop Med J. 1995 Apr;33(2):75-81.
This retrospective study provides information on the clinical findings and response to therapy in Ethiopian children with idiopathic thrombocytopenic purpura. Forty-nine cases of idiopathic thrombocytopenic purpura admitted to the teaching hospital, Ethio-Swedish Children's Hospital (ESCH) in Addis Abeba, Ethiopia between January 1982 and December 1993 were studied. Among these were 31 females and 18 males with a female to male ratio of 1.9:1. The age range was three to 12 years with a mean of seven years. The commonest presenting clinical features were petechiae, epistaxis, gingival and gastro-intestinal bleeding. Twenty-nine patients were treated with prednisolone, out of whom, 27 attained absolute remission. Twenty patients were observed and managed conservatively and attained spontaneous remission. One child went on to develop chronic idiopathic thrombocytopenic purpura and underwent splenectomy after immunosuppressive treatment failure, while another child is still being followed up with recurrent episodes of thrombocytopenia and epistaxis. No mortality was noted in the review of these series of patients.
这项回顾性研究提供了有关埃塞俄比亚特发性血小板减少性紫癜患儿的临床发现及治疗反应的信息。对1982年1月至1993年12月间收治于埃塞俄比亚亚的斯亚贝巴的埃塞俄比亚-瑞典儿童医院（ESCH）教学医院的49例特发性血小板减少性紫癜病例进行了研究。其中有31名女性和18名男性，男女比例为1.9:1。年龄范围为3至12岁，平均年龄为7岁。最常见的临床表现为瘀点、鼻出血、牙龈出血和胃肠道出血。29例患者接受了泼尼松龙治疗，其中27例实现了完全缓解。20例患者接受了观察并进行了保守治疗，实现了自发缓解。1名儿童发展为慢性特发性血小板减少性紫癜，在免疫抑制治疗失败后接受了脾切除术，而另1名儿童仍在因血小板减少和鼻出血反复发作而接受随访。在对这一系列患者的回顾中未发现死亡病例。
