Bobde V, Durani S, Pattabhi V, Sadasivan C
Department of Chemistry, I.I.T. Powai, Bombay, India.
Int J Pept Protein Res. 1995 Apr;45(4):332-6. doi: 10.1111/j.1399-3011.1995.tb01046.x.
The crystal structure of a heterochiral peptide, viz. Boc-D-Val-Ala-Leu-Ala-OMe, with a D-residue in the beginning of the sequence has been determined (a = 9.464(5), b = 35.615(5), c = 9.703(2) A, space group P2(1)2(1)2, Z = 4, R = 0.09). The peptide is in the extended beta-conformation and the packing is stabilised by four N--H ... O hydrogen bonds in an antiparallel beta-sheet arrangement. The solvent molecule is disordered and does not have any specific interactions with the peptide.
已确定一种异手性肽（即Boc-D-缬氨酸-丙氨酸-亮氨酸-丙氨酸-甲酯）的晶体结构，该肽在序列起始处含有一个D-残基（a = 9.464(5)，b = 35.615(5)，c = 9.703(2) Å，空间群P2(1)2(1)2，Z = 4，R = 0.09）。该肽呈伸展的β-构象，堆积通过反平行β-折叠排列中的四个N-H...O氢键得以稳定。溶剂分子无序，且与该肽没有任何特定相互作用。
