维生素B12缺乏症：诊断不足、治疗过度？

Vitamin B12 deficiency: underdiagnosed, overtreated?

作者信息

Schilling R F, Williams W J

机构信息

University of Wisconsin Medical School, Madison, USA.

出版信息

Hosp Pract (1995). 1995 Jul 15;30(7):47-52; discussion 52, 54. doi: 10.1080/21548331.1995.11443228.

DOI:10.1080/21548331.1995.11443228

PMID:7601897

Abstract

Neurologic damage may become permanent when the disorder is mistaken for multiple sclerosis or diabetic neuropathy--hence the need for prompt parenteral B12 in patients with pernicious anemia. The need for B12 injections is questionable for patients with achlorhydria and for those with a marginal or low serum B12 level but no signs or symptoms of deficiency.

摘要

当这种病症被误诊为多发性硬化症或糖尿病性神经病变时，神经损伤可能会变成永久性的——因此，恶性贫血患者需要及时进行肠胃外补充维生素B12。对于胃酸缺乏的患者以及血清维生素B12水平处于临界值或偏低但没有缺乏迹象或症状的患者，是否需要注射维生素B12仍存在疑问。