Asch R H, Bryner J, Watatani H, Mills T, Greenblatt R B
South Med J. 1979 Jan;72(1):72-4. doi: 10.1097/00007611-197901000-00020.
The case of a patient with premature ovarian failure and a history of polycystic ovarian disease was described. Dynamic gonadal and pituitary tests were done. Ovarian, adrenal, and peripheral veins were catheterized to determine the steroid secretion under HCG stimulation. In vitro studies of the capacity of ovarian steroidogenesis confirmed the refractory nature of the gonad. Lack of gonadal response, both in vivo and in vitro, to stimulation suggests a possible alteration in ovarian sensitivity to gonadotropins as a possible cause of premature menopause.
描述了一名患有卵巢早衰且有多囊卵巢疾病史的患者病例。进行了动态性腺和垂体检查。通过插入卵巢、肾上腺和外周静脉导管来测定人绒毛膜促性腺激素（HCG）刺激下的类固醇分泌。卵巢类固醇生成能力的体外研究证实了性腺的难治性。体内和体外对刺激均缺乏性腺反应，提示卵巢对促性腺激素敏感性可能发生改变，这可能是过早绝经的一个原因。
