嗜铬粒蛋白A：甲状旁腺分泌的一种新型调节因子。

Chromogranin A: a novel regulator of parathyroid gland secretion.

作者信息

Cohn D V, Fasciotto B H, Reese B K, Zhang J X

机构信息

Department of Biological and Biophysical Sciences, University of Louisville, KY 40292, USA.

出版信息

J Nutr. 1995 Jul;125(7 Suppl):2015S-2019S. doi: 10.1093/jn/125.suppl_7.2015S.

DOI:10.1093/jn/125.suppl_7.2015S

PMID:7602385

Abstract

Chromogranin A (CgA) is a major protein of the parathyroid gland that is costored and cosecreted with parathyroid hormone (PTH). CgA, widely distributed in endocrine and neuroendocrine cells in addition to parathyroid cells, appears to be a precursor of biologically active autocrine or paracrine peptides that include pancreastatin (CgA240-288) and parastatatin (CgA347-419), compounds that strongly inhibit stimulated secretion of PTH and costored CgA. The biosynthesis of CgA and PTH via gene expression and mRNA translation are noncoordinately altered by agents that affect parathyroid cell secretion including 1,25 dihydroxycholecalciferol, dexamethasone and Ca2+. These data have been interpreted to support an important physiological role for CgA-derived peptides as autocrine, paracrine and endocrine agents in the regulation of parathyroid cell function and secretion.

摘要

嗜铬粒蛋白A（CgA）是甲状旁腺的一种主要蛋白质，它与甲状旁腺激素（PTH）共同储存和分泌。CgA除了分布于甲状旁腺细胞外，还广泛分布于内分泌和神经内分泌细胞中，它似乎是生物活性自分泌或旁分泌肽的前体，这些肽包括胰抑制素（CgA240 - 288）和甲状旁抑制素（CgA347 - 419），这些化合物能强烈抑制PTH和共同储存的CgA的刺激分泌。通过基因表达和mRNA翻译对CgA和PTH进行的生物合成，会受到影响甲状旁腺细胞分泌的物质（包括骨化三醇、地塞米松和Ca2+）的非协调性改变。这些数据被解释为支持CgA衍生肽作为自分泌、旁分泌和内分泌因子在调节甲状旁腺细胞功能和分泌中具有重要生理作用。