Seow W K, Hertzberg J
University of Queensland Dental School, Brisbane, Australia.
Pediatr Dent. 1995 Mar-Apr;17(2):101-5.
Cleidocranial dysplasia (CD) is an autosomal dominant skeletal disorder with characteristic dental findings of numerous supernumerary teeth and noneruption of permanent teeth. This investigation compared the dental development and root lengths of the mandibular first permanent molar in 11 CD patients with those of 22 healthy, normal children matched for race, age and sex. The results showed that children with CD experienced a delay in dental development of approximately 3 years compared with normal children (P < 0.05). In addition, the root lengths of the mandibular first permanent molar were significantly longer than those of the comparison children (17.8 +/- 1.6 mm vs 13.6 +/- 1.2 mm (P < 0.001). This study thus revealed two significant clinical features of CD: 1) severe delay in dental development, and 2) excessive root lengths of mandibular permanent first molars. These features may be important in the pathogenesis of delayed dental eruption observed in this disorder.
锁骨颅骨发育不全（CD）是一种常染色体显性遗传性骨骼疾病，其特征性的牙齿表现为多生牙数量众多且恒牙萌出障碍。本研究比较了11例CD患者与22例种族、年龄和性别相匹配的健康正常儿童下颌第一恒磨牙的牙齿发育情况和牙根长度。结果显示，与正常儿童相比，CD患儿的牙齿发育延迟约3年（P < 0.05）。此外，下颌第一恒磨牙的牙根长度明显长于对照组儿童（17.8 +/- 1.6 mm对13.6 +/- 1.2 mm，P < 0.001）。因此，本研究揭示了CD的两个重要临床特征：1）牙齿发育严重延迟，2）下颌第一恒磨牙牙根过长。这些特征可能在该疾病中观察到的牙齿萌出延迟的发病机制中起重要作用。
